MHCombiotic (MHC)
Is a preclinical biotech company pioneering the development our innovative antimicrobial (CombioticsTM) to control infection & Antimicrobial Resistance (AMR).
Core Technology
Synergistic combination of plant-based small molecules with inorganic salts.
Mechanism of Action: Our comprehensive multi-OMICS studies, combined with probe-based assays, have shown that our plant-based agents target the bacterial cell membrane in the initial step. The bacterial cell membrane has a composition that is markedly different from eukaryotic cell membranes, explaining the agents’ selectivity and thus their safety as antibacterial agents. Moreover, these agents increase glutathione (GSH) levels in eukaryotic cells. GSH is a powerful antioxidant known for its anti-inflammatory properties, playing a crucial role in protecting cells from oxidative stress and reducing inflammation in the body. As a tripeptide composed of glutamine, cysteine, and glycine, GSH is vital for maintaining cellular health and immune function, acting like a shield for human cells. On the other hand, inorganic salts primarily affect four cellular processes of bacteria: sulfur homeostasis, reactive oxygen species response (by disrupting iron-sulfur (Fe–S) clusters), energy pathways, and the bacterial cell membrane.
Research
Our team combines decades of state-of-the-art Antimicrobial Resistance (AMR) elimination scientific research – having conducted over 10,000 tests over 3 years – with world-leading subject experts, top universities, and private pharma lab teams, to discover the most efficacious and cost-effective solution to deploy globally and urgently.
Discovery
With our world-class facilities and our extensive academic, and scientific experience, we are discovering novel and safe antimicrobials with different properties and expenditures.
Collaboration
We are collaborating with various top global research institutes and industries to develop our state-of-the-art technology.
We are interested in collaborating with any relevant industry and academic institutions.
R&D
We are the ideal strategic partner and supplier of innovation and R&D support.
“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.”
